Nederlands tijdschrift voor geneeskunde
-
Ned Tijdschr Geneeskd · Jan 2008
Case Reports[Diagnostic image (358). A neonate with splenomegaly and calcified adrenal glands].
A 10-day-old male neonate with feeding problems and splenomegaly had bilateral adrenal calcifications on plain abdominal X-ray caused by Wolman disease.
-
Ned Tijdschr Geneeskd · Jan 2008
[Neurological defects and developmental disorders following neonatal extracorporeal membrane oxygenation: results of a follow-up study after 5 years].
Descriptive study of the development of children 5 years after neonatal extracorporeal membrane oxygenation (ECMO). ⋯ A significant proportion ofthe children that had been treated with ECMO had long-term morbidity in the form of neurological defects and developmental disorders.
-
Ned Tijdschr Geneeskd · Jan 2008
[Fortification of food with folic acid diminishes the number of neural tube defects].
A recent study from a research group from Quebec showed a strong decrease in the number of births affected by a neural tube defect since folic acid fortification was introduced in Canada. The prevalence decreased from 1.58 neural tube defects per 1000 births before the introduction of folic acid fortification to 0.86 per 1000 births in the period of complete fortification. ⋯ More research is needed to determine which population groups are at risk of possible negative effects of folic acid fortification and at which level of fortification. Until then, it is important to generate more attention and publicity in order to increase awareness and knowledge concerning folic acid and to promote its use before and after conception.
-
Ned Tijdschr Geneeskd · Jan 2008
[The reporting of observational studies: useful and appreciable recommendations for improvement].
Much biomedical research is observational. Research should be reported in a way that enables the reader to comprehend the original objectives of the researchers, their subsequent actions and findings, and conclusions. ⋯ These 22 recommendations are summarised here with a commentary. These recommendations concern the title, the abstract, the introduction, the description of the methods and the results, the discussion and a list of the financiers of the study.
-
--The incidence of type 2 diabetes mellitus is increasing, as is the rate of related long-term complications. --Increased body weight and lack of exercise are the major non-genetic factors that are responsible for the increased incidence of type 2 diabetes mellitus. --People predisposed to developing type 2 diabetes mellitus can be identified easily by taking a patient history (e.g. genetic predisposition, gestational diabetes, medication), performing a physical examination (e.g. body-mass index, fat distribution) and laboratory tests (e.g. impaired fasting and post-load blood glucose levels). --Intensive lifestyle modifications reduce the risk of type 2 diabetes mellitus by 42-58%. --Drug therapy is less effective than lifestyle modifications in the prevention of type 2 diabetes mellitus. Moreover, the disease course after treatment is discontinued is unknown. --Successful intervention resulting in a sustained effect is expected to have a preventive effect on the long-term complications of type 2 diabetes mellitus.