Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Sep 2008
[Obtaining medical ethical approval for a multicentre, randomised study: prospective evaluation of a ponderous process].
To evaluate the procedure to obtain medical ethical approval for a multicentre study in the Netherlands. ⋯ Obtaining medical ethical approval for this multicentre trial in the Netherlands was a long and inefficient process, requiring a considerable investment of time and resources. Streamlining the application procedure may lead to a substantial reduction in the current unnecessary delay of starting a multicentre study.
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Ned Tijdschr Geneeskd · Sep 2008
Letter[Establishment of a national registry for sudden cardiac arrest in athletes].
Physical activity is healthy but can also trigger sudden cardiac arrest in vulnerable subjects. A Dutch national registry of sudden cardiac arrest in athletes has been established under the name of SPORTCOR. ⋯ Medical doctors and family members can register cases of sudden cardiac arrest in athletes at the website www.sportcor.nl. The website also provides background information for those who are interested.
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Ned Tijdschr Geneeskd · Aug 2008
Case Reports[Unexplained right-sided heart failure following open heart surgery: mind the pericardium].
Three men, aged 67 years, 80 years and 53 years, respectively, developed signs and symptoms of progressive right-sided heart failure following open heart surgery. They were diagnosed with constrictive pericarditis based on echocardiography, cardiac magnetic resonance and cardiac catheterisation. Following pericardiectomy, two of the patients fully recovered, while one, the 80-year-old man, died during convalescence. ⋯ However, it is important to recognise this disorder early before it has progressed to an advanced stage. Pericardiectomy is the only effective therapy. When performed too late, survival is significantly reduced.
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Ned Tijdschr Geneeskd · Aug 2008
[Treatment of recurrent Clostridium difficile-associated diarrhoea with a suspension of donor faeces].
To study the effect of treating recurrent Clostridium difficile-associated diarrhoea (CDAD) with a suspension of donor faeces. ⋯ Treatment with donor faeces seems promising for patients who develop repeated recurrences despite adequate therapy and could be valuable in the future during (local) epidemics of the PCR ribotype 027 strain. A randomised nationwide study (FECAL trial) has been started in order to determine the efficacy of this treatment.