Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Nov 2004
Review[Risk factors for skin melanoma: genetic factors probably more important than exposure to sunlight].
Pigmented naevi (moles) are increasingly regarded as risk factors for the development of melanoma. The probability of melanoma developing from congenital naevi is proportional to the volume of the naevi. The risk of melanoma development from large naevi (diameter > 20 cm) is already present in the early years of childhood. ⋯ Recent research has shown that dysplastic naevi synthesise more phaeomelanin. There are also strong indications that dysplastic naevus cells suffer from chronic oxidative stress. This situation can lead to hypermutability and genetical instability.
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Two 37-year-old men, both drug addicts, and a 32-year-old homeless woman presented themselves with a painful arm. Except for the first patient, there was a delay in diagnosing the compartment syndrome of the arm. In the first patient emergency fasciotomy led to a good functional recovery, however kidney function was lost despite proper treatment, possibly due to combined heroine use and muscle breakdown. ⋯ Major early symptoms of compartment syndrome are progressive disproportional pain and sensory loss, not relieved by analgesia. If left untreated, the ischaemic tissue damage is potentially limb and even life threatening. The acute compartment syndrome is a clinical diagnosis and a low threshold for surgical exploration and fasciotomy is advocated.
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In two patients, a girl aged 2 and a man aged 52 years, who had suffered a severe crush trauma, acute compartment syndrome of the foot was diagnosed. Decompression by means of one medial and two dorsal dermato-fasciotomy incisions was carried out and fractures of the metatarsals were repaired using K-wires. The girl recovered completely, but the man developed progressive necrosis in the flexors of the foot and on the skin on the foot sole which necessitated amputation of the foot. ⋯ A combined medial and dorsal approach is adopted to release the foot compartments; three incisions are usually sufficient. If fractures are present, these are repaired at the same time. Within four hours an unnoticed compartment syndrome can lead to irreversible ischaemia of the nerves and muscle tissue with long-term irreversible consequences.
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Ned Tijdschr Geneeskd · Oct 2004
Case Reports[Implantable cardioverter-defibrillator in the treatment of two patients with an increased risk of sudden cardiac death].
A 23-year-old female with familial long-QT syndrome and a 48-year-old male with familial dilated cardiomyopathy were given an implantable cardioverter-defibrillator (ICD) as prophylaxis. About half a year after the implantation, there was an appropriate and successful ICD-discharge in both patients in connection with ventricular tachycardia. Treatment with an ICD can be life-saving in patients with cardiac rhythm disorders. The most common indication is ventricular tachycardia or fibrillation due to ischaemic heart disease, but an ICD may also be indicated in patients with cardiomyopathy, congenital heart disease, hereditary arrhythmia or a planned heart transplantation.
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Ned Tijdschr Geneeskd · Oct 2004
Case Reports[Diagnostic image (212). A man with severe abdominal pain].
A 36-year-old man presented with acute abdominal pain due to occlusion of the superior mesenteric artery associated with intestinal rotation caused by an upper abdominal postoperative adhesion.