Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Jan 2002
[Predictive value of chills in patients presenting with fever to urgent care department].
To ascertain the correlation between chills, bacteraemia, infection type and clinical progress in patients presenting with fever to the casualty department. ⋯ There was a strong correlation between the chill indicated in the anamnesis and bacteraemia, especially in patients with a urinary tract infection. Bacteraemia, advanced age and serious comorbidity were unfavourable prognostic factors.
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Ned Tijdschr Geneeskd · Jan 2002
Case Reports[STI571: a new dimension in the treatment of chronic myeloid leukemia].
Three patients suffering from chronic myelogenous leukaemia (CML), a 36-year-old woman in blast crisis, and a 64-year-old woman and a 60-year-old man in the chronic phase, participated in a clinical trial with STI571, a recently developed tyrosine kinase inhibitor with relative specificity for the BCR-ABL kinase. In all three patients, complete haematologic remission occurred within 2 months of the treatment being initiated. Subsequently the patient in blast crisis underwent allogeneic stem-cell transplantation. ⋯ The development of STI571 is a major breakthrough in the treatment of CML. There are few side effects and the short-term results are excellent in specific patient categories. Further research is needed to establish the eventual role of STI571 in the treatment of CML.