Acta Medica Port
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Multicenter Study
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study.
Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction. ⋯ Raltegravir-based regimens seem like a valid therapeutic option in heterogeneous populations of HIV-infected patients, in patients with previous ART experience and as part of first-line therapeutic options alongside with the latest generation of drugs from its class.
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The Western Ontario Shoulder Instability Index (WOSI) is a self-administered questionnaire specifically used to determine the impact of shoulder instability on quality of life. The aim of this study was to translate the WOSI into European Portuguese and analyze its validity and reliability in a population with shoulder instability. ⋯ WOSI-PT is a reliable and valid instrument for assessing the functional impact of shoulder joint instability on quality of life.
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Case Reports
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies.
Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. ⋯ As for the latter, the detection of anti-HMGCR antibodies is performed on tissue sections by indirect immunofluorescence and is characterized by a typical fluorescence pattern called "HMGCR Associated Liver IFL Pattern". The authors present two case reports that show the importance of diagnosing statin-induced necrotizing myopathy as quickly as possible and the contribution of anti-HMGCR antibody detection for the diagnosis.
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Pediatric readmissions have received increased attention in the past few years. Distinguishing between planned and unplanned readmissions and between preventable and unpreventable ones constitutes an important target to better understand this thematic. The aim of this study was to analyze the readmission rate and characterize the population readmitted within a 30-day period after discharge in the pediatric ward of a level II hospital. ⋯ We found a low overall readmission rate, but a higher percentage of potentially preventable readmissions, when compared with the available literature.