Ann Acad Med Singap
-
Ann Acad Med Singap · Dec 2024
Intrapleural fibrinolytic therapy for pleural infections: Outcomes from a cohort study.
Pleural infections are a significant cause of mortality. Intrapleural fibrinolytic therapy (IPFT) utilising alteplase and dornase is a treatment option for patients unsuitable for surgery. The optimal dose of alteplase is unknown, and factors affecting treatment success in an Asian population are unclear. We sought to determine the factors affecting treatment success in Tan Tock Seng Hospital, Singapore and evaluate the efficacy of lower doses of IPFT. ⋯ Lower starting doses of alteplase remain effective in the treatment of pleural infection. Early IPFT may result in better outcomes.