Ann Acad Med Singap
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Ann Acad Med Singap · Sep 2018
ReviewCancer Immunotherapy - The Target is Precisely on The Cancer and Also Not.
In recent years, the impressive number of cancer immunotherapy drugs approved has been unprecedented-building on over a century of understanding on how the immune system combats cancer, and how cancer evades it. Leading the charge are the immune checkpoint inhibitor monoclonal antibodies, and adoptive cell therapy with chimeric- antigen-receptor (CAR)-T cell therapy. These breakthrough therapies have led to improved survival in patients with many advanced cancers. ⋯ Early clinical trials of neoantigen vaccines have provided proof-of-principle efficacy, especially in melanoma patients. Combinations of immunotherapies through rational design are underway aiming to further improve clinical outcomes. Moving forward, cancer immunotherapy will gain even more momentum from the discovery of more cancer targets-both on the cancer itself and in the tumour microenvironment as well as the identification of biomarkers of treatment resistance and efficacy.
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Ann Acad Med Singap · Sep 2018
Deliberate Self-Harm in Psychiatric Outpatients Aged 14-35 Years in Singapore.
The main aim of the study was to identify the prevalence of deliberate self-harm (DSH) in a sample of youth outpatients attending the state psychiatric hospital in Singapore and to identify the sociodemographic and psychological/clinical risk factors associated with DSH. The secondary aim of the study was to examine if different forms of DSH had distinguishing risk factors. ⋯ There was a high prevalence of DSH in the psychiatric outpatient population. The risk factors identified in this study are consistent with those of international studies which point to their stability across cultures.
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Abstract
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Abstract
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Ann Acad Med Singap · Sep 2018
LetterTrends in Cataract Surgery Technique and Anaesthesia Preferences in Singapore: A 2016 Survey.
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