Arch Intern Med
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base.
A combination metered-dose inhaler aerosol containing ipratropium bromide and albuterol sulfate has been reported to be more effective than either of its components in patients with chronic obstructive pulmonary disease. The dose of albuterol sulfate is equal in moles per liter to the dose of albuterol base used in the commercially available metered-dose inhalers. ⋯ We conclude that a combination of ipratropium bromide and albuterol sulfate is more effective at improving pulmonary function than albuterol base alone, with no potentiation of adverse effects.
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Most patients undergoing in-hospital cardiac resuscitation will not survive to hospital discharge. ⋯ A practical and highly sensitive decision rule has been derived that identifies patients with no chance of surviving in-hospital cardiac arrest. Prospective validation of the rule is necessary before it can be used clinically.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Oral vs intravenous ciprofloxacin in the initial empirical management of severe pyelonephritis or complicated urinary tract infections: a prospective randomized clinical trial.
There are few data on the efficacy of oral antibiotics in the initial empirical management of severe forms of urinary tract infection (UTI). ⋯ In the hospital setting, oral ciprofloxacin is as effective as the intravenous regimen in the initial empirical management of serious UTIs, including bacteremic forms, in patients without severe sepsis, obstruction, or renal foci of suppuration. The efficacy of the oral regimen indicates a potential use for ciprofloxacin in outpatient treatment of a subset of patients currently hospitalized on account of disease severity.