Arch Iran Med
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Review
Urgent Alert: Potential Risk of Dengue Infection Transmission Through Blood Transfusion in Iran.
Dengue infection is an emerging public health issue in Iran, with about 149 confirmed newly infected cases. It can be transmitted by the bite of infected Aedes mosquitoes and even nosocomial routes. ⋯ Given the possibility of the transmission of dengue infection through transfusion, it is important to implement policies to improve blood safety. Proper donor selection by utilizing appropriate blood donor questionnaires and performing general physical examinations, along with performing sensitive diagnostic tests on blood donor samples, utilizing pathogen reduction techniques, and implementing lookback programs, can be effective in reducing the risk of transfusion-transmitted dengue virus (TT-DENV).
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Historical Article
Consequences of Infectious Disease Outbreaks in Ardabil (1925-1941): A Historical Analysis.
Infectious diseases were one of the most important public health problems in Ardabil during the first Pahlavi period (1925-1941 AD). These diseases caused the illness and death of many people. The purpose of this study is to investigate the factors and consequences of the spread of infectious diseases in Ardabil during the first Pahlavi period. ⋯ Poverty, illiteracy, poor public health, lack of medical facilities, and the geographical location were the main factors in the spread of these diseases. Considering the critical nature of the issue, the first Pahlavi government tried to control and prevent diseases by carrying out measures such as public education, establishing health and treatment centers and reforming their structure, sending doctors and distributing medicine, and implementing quarantine and vaccination. The results showed that the efforts of the first Pahlavi government in fighting infectious diseases in Ardabil were relatively successful and reduced the prevalence of some diseases.
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We present a case with an intrathoracic caudate lobe in a 45-year-old woman who referred with a complaint of nonspecific chest pain. She denied previous history of trauma or surgery. ⋯ In the coronal plane, the mass was protruding to the abdomen and had similar density with liver. Magnetic resonance imaging confirmed the diagnosis.
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Here, we report a case with concomitant variants: a novel homozygous HERC1 gene variant and a novel heterozygous PMP22 duplication. The 2-year-old male presented with seizures, developmental delay, macrocephaly, hypotonia, unilateral hypertrophy, thoracic scoliosis, normal brain MRI, and elevated homocysteine level which normalized after treatment. ⋯ The case underscores the challenges in understanding genotype-phenotype correlations and suggests a potential interplay between these genetic variants in shaping the current and future clinical phenotype of the patient. In the case of genetic diseases, this event may have important implications on family members' counseling, and concomitant variants in Charcot-Marie-Tooth (CMT) families should be considered when significant intra-familial clinical heterogeneity is observed.
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Blood cancers account for a significant proportion of cancer-related deaths worldwide. In this study, hematological cancer mortality in northern Iran was examined during 2013-2021, along with age-adjusted mortality rates. ⋯ The trend of hematological malignancies in Babol city is increasing across all age groups and in both sexes. This study emphasizes the need for effective prevention and treatment strategies, including improving access to cancer care, enhancing surveillance in families with blood malignancies and reducing modifiable risk factors. Additionally, further research is warranted to develop targeted interventions.