B Acad Nat Med Paris
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B Acad Nat Med Paris · Jan 1998
Review[Arsenic and retinoic acid, towards targeted treatments of acute promyelocytic leukemia?].
Acute promyelocytic leukaemia is a key model system in cancer biology. Its exquisite sensitivity to retinoic acid constitutes the first example of differentiation therapy. ⋯ The fusion protein also delocalizes PML and other nuclear body antigens and this alteration of nuclear protein traffic seems to play a role in growth control and apoptosis. The clinical response of this disease to retinoids and arsenic trioxide, both of which induce the degradation of the fusion protein, constitute the first example of a therapy directly targeted to a specific genetic lesion in a human cancer.
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B Acad Nat Med Paris · Jan 1998
Case Reports[A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency].
delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis. We described in two siblings a paradoxical hyperammonemia with hypoprolinemia and hypoornithinemia associated to bilateral cataract, mental retardation, joint laxity and skin hyperelasticity. ⋯ Both patients are homozygous for an L396S substitution, this amino acid being highly conserved across species. This is the first report of a P5C synthetase deficiency in human.
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B Acad Nat Med Paris · Nov 1997
[Recourse to care and morbidity of the homeless in the Paris district].
The disparities of access to care and morbidity according to different socio-economic characteristics are highlighted over about thirty years; what is the situation with regard to the homeless, the least provided for, who in some sense lie at the limits of the social scale? We present data on hospitalizations, ambulatory care and the morbidity declared by the homeless revealed in the INED survey of February-March 1995 in the Paris region. We tried to compare hospitalizations and physician care of the homeless with the population of "ordinary households" in the same region on the basis of different statistical sources. Hospitalizations are considerably more numerous in this group than in the rest of the population which indicates that the homeless are more exposed to diseases and accidents; on the other hand, taking into account any possible errors of observation, the homeless and the general population seem to have the same rate of recourse to outpatient doctor treatment. Is this also the case for complementary examinations, biological tests and medical imagery?
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B Acad Nat Med Paris · May 1996
Review[Physiopathologic consequences of underwater diving and medical management of divers].
Underwater diving is a very closely medically managed activity. Performing it, the human organism is under the physical laws of pressure and following consequences. The expiratory flows are significatively reduced, enhancing the risk of alveolar hypoventilation at exertion, the central nervous system is the privileged target during inopportune tissue degassing related accidents (leaving 20% of sequellae), barotraumatic injuries threaten middle and inner ear or lung (pulmonary barotrauma is the most severe accident), the toxicity of gas under pressure (i.e. oxygen, nitrogen) exposes to specific risks of loss of consciousness. ⋯ It continues during tuition time by teaching him the physiopathology of accidents, their prevention and first cares. Finally, in case of accident, a specialized medical team acts in diagnosis and treatment. From these points of view, diving medicine is a multispecialty medical matter.