Chinese Med J Peking
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Chinese Med J Peking · Dec 2000
Advanced glycosylation end products, protein kinase C and renal alterations in diabetic rats.
To study the relationship between advanced glycosylation end products (AGE) and protein kinase C (PKC), and their effects on renal alteration in diabetic rats. ⋯ Chronic hyperglycemia may lead to an increase of PKC activity. HbA1c and AGE may not directly contribute to alterations of PKC activity, but the increase of PKC activity could promote the action of AGE on GBM thickening. It is important to inhibit the formation of AGE and reduce the PKC activity so as to prevent or delay the development of diabetic nephropathy.
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Chinese Med J Peking · Nov 2000
Randomized Controlled Trial Comparative Study Clinical TrialA comparative study of the dose-response and time course of recovery of atracurium and rocuronium.
To compare the characteristics of the dose-response relationship and the time course of action between atracurium and rocuronium in adult patients anesthetized with N2O-O2-fentanyl-thiopene. ⋯ Atracurium and rocuronium are low-potency nondepolarizing relaxants with intermediate duration. As compared to atracurium, the neuromuscular blocking effect of rocuronium was about 20% less potent and its duration of action was shorter.
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Chinese Med J Peking · Sep 2000
Hyperbaric oxygen preconditioning induces neuroprotection against ischemia in transient not permanent middle cerebral artery occlusion rat model.
This study was designed to determine if repeated hyperbaric oxygen (HBO) exposure induces ischemic tolerance in focal cerebral ischemia. ⋯ The present study demonstrated that HBO preconditioning can induce ischemic tolerance in transient not permanent MCAO rats in a "dose-dependent" manner.