Chinese Med J Peking
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Chinese Med J Peking · Nov 1999
Molecular mechanism of recessive congenital methemoglobinemia in Chinese pedigrees.
To investigate the molecular mechanism of recessive congenital methemoglobinemia (RCM) in Chinese and to establish a gene diagnostic method of polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). ⋯ A guanine-to-adenine transition at codon 57, replacing arginine with glutamine, was the molecular basis for RCM in two Chinese families.
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Chinese Med J Peking · Sep 1999
Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China.
To investigate the possible relationship between bone mineral density and polymorphism of the estrogen receptor (ER) gene in Shanghai healthy postmenopausal women. ⋯ There is significant relationship between the polymorphism of ER gene and both Lumbar 2-4 BMD and Troch BMD. It is significant to explore the pathogenesis of osteoporosis and to prevent the development of osteoprosis by use of molecular genetics.
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Chinese Med J Peking · Sep 1999
Serum leptin levels and adiposity in adult Chinese: a preliminary observation.
To establish normal serum leptin levels in Chinese and investigate the relationship between serum leptin levels and body fat, gender, age and androgen. ⋯ Serum leptin levels in Chinese lean people are similar to those in Caucasians and in both lean and obese groups, the leptin levels are correlated with BMI, suggesting that the great majority of the obese patients are resistant to endogenous leptin. Those who are relatively deficient of leptin may become a group of good candidates for leptin treatment in the future.
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Chinese Med J Peking · Sep 1999
Relationship between angiotensinogen gene M235T variant with diabetic nephropathy in Chinese NIDDM.
To investigate whether angiotensinogen (AGT) gene M235T variant is associated with non-insulin-dependent diabetes mellitus without nephropathy (DN-), and diabetic nephropathy (DN+) in Chinese non-insulin-dependent diabetes mellitus (NIDDM). ⋯ AGT gene M235T polymorphism is associated with diabetic nephropathy in NIDDM. TT genotype of the AGT gene might be an independent risk factor of diabetic nephropathy in Chinese NIDDM patients.