Chinese Med J Peking
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Chinese Med J Peking · Aug 1991
Localization and changes of hemorrhagic fever with renal syndrome virus in lymphocyte subpopulation.
Double-labeled immunocytochemistry was used for studying the localization and distribution of hemorrhagic fever with renal syndrome virus (HFRSV) antigen in the peripheral blood lymphocyte subpopulations in HFRS patients and the quantitative changes of these subpopulations. It was found that HFRSV might infect different subpopulations of lymphocytes. The infection rate of B cells (31.3%) was significantly higher than that of T cells (8.5%), and the infection rate of CD8+ subpopulation (10.5%) was significantly higher than that of CD4+ subpopulation (6.1%). ⋯ From febrile to oliguric stage, the number of CD8+ cells increased gradually, leading to a decrease and reverse of CD4/CD8 ratio, while the number of CD4+ cells remained almost unchanged. The appearance and disappearance of HFRSV in lymphocytes were closely associated with the dynamic changes of CD4/CD8 ratio and HLA-DR and Tac expressions. The results suggested that there were certain differences in HFRSV infectivity of different lymphocyte subpopulations, which might be due to the disorders of immunoregulation and immunopathology of HFRS.
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Chinese Med J Peking · Jun 1991
Influence of flexion-extension motion of lumbar spine on lumbosacral dural sac. An experimental study.
To analyze the effects of flexion-extension motion of lumbar spine on the position and shape of lumbosacral dural sac, 10 flexion/extension lateral myelograms of cadaver specimens of normal lumbar spine were measured. The results showed that moving from flexion to extension both sagittal diameter and length of the dural sac decreased significantly, the dural sac moved caudally, and the sagittal diameter of the anterior epidural space decreased in the mid-vertebral level but increased in the intervertebral level. The dynamic changes of the dural sac and their influence factors and clinical relevance were discussed.
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Chinese Med J Peking · May 1991
CT-guided stereotactic evacuation of hypertensive intracerebral hematoma.
From January 1986 to June 1989, the CT-guided stereotactic evacuation was performed in 38 cases of hypertensive intracerebral hematoma with satisfactory result. 24 patients were male and 14 female. The age ranged from 37 to 78 years, with an average of 55. 24 cases had their hematoma in internal capsule, 7 in cerebellum, 5 in subcortex, and 2 in brain stem. The interval between the occurrence of hemorrhage and evacuation of hematoma was 24 hours or less in 18 cases, 2-3 days in 14 and 4-7 days in 6. The volume of hematoma was estimated by CT scanning being more than 100 ml in 6 cases whereas much less in 2 cases of the brain stem.
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Chinese Med J Peking · Dec 1990
Study of SOS-inducing kinetics and inhibitory effect on induction of Escherichia coli.
It was found that modified pulse induction could produce SOS responses of the sfi gene in 15 minutes. The responses peaked at 30-60 minutes and were twice as strong as those by persistent induction. ⋯ A suppressive effect on 4NQO-induced SOS response by cinnamic aldehyde and diallyl trisulfate was also observed. The effect might be due to an interference with the metabolic activation of 4NQO or breakdown of 4NQO by the bacteria.