Clin Med
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Case Reports
Transfusion-related acute lung injury: a rare and life-threatening complication of a common procedure.
Transfusion-related acute lung injury (TRALI) has emerged as one of the leading causes of transfusion-related morbidity and mortality and is undoubtedly under diagnosed. It is a serious pulmonary syndrome that can lead to death if not recognised and treated promptly. The diagnosis of TRALI is based primarily upon clinical signs and symptoms and is, in part, a diagnosis of exclusion.
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Fatigue and stress-related illnesses often become diagnoses of exclusion after extensive investigation. 'Tired all the time' is a frequent reason for referral to the endocrine clinic, the implicit question being--is there a subtle endocrine pathology contributing to the patient's symptoms? Often initial assessment suggests not but there are no clear data to address the question of whether overt pathology will develop in the future. This study observed outcomes after five years in 101 consecutive and unselected referrals to secondary care for 'fatigue?cause', where initial assessment did not suggest treatable endocrine pathology. The findings suggest that the clinical diagnosis of fatigue, based on history and tests to exclude anaemia, hypothyroidism and diabetes, is secure: these patients do not subsequently demonstrate excess morbidity and mortality, and their presenting symptoms are not early features of significant endocrine pathology.
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This one-day conference for senior clinicians and NHS managers was a partnership between the King's Fund, Royal College of Physicians (RCP) and Royal College of General Practitioners (RCGP). It explored clinical partnerships and integrated care by examining how to develop constructive and workable relationships between generalists and specialists that harness clinical skills, support professional practice and deliver excellent care to patients.