Clin Med
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The past decade has seen the development of a network of specialist teenage and young adult cancer centres across the UK. These provide expertise in treatment across the spectrum of malignancies that occur in young adults, supported by multi-disciplinary teams that are able to provide the psycho-social support so necessary for this age group, and in a hospital environment that encourages social interaction while delivering expert medical care. The development of teenage and young adult (TYA) cancer as a specialty gained establishment backing in 2005, through NICE guidance which mandated that all 16- to 24-year-olds should be referred to specialist TYA cancer centres. The foundation of this achievement was set by a handful of committed individuals and the Teenage Cancer Trust, a charity that has acted as patient advocate and political pressure group, and that has brought to public attention the need for change while providing support for specialist staff and hospitals.
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One percent of laboratory samples are rejected as 'unsuitable for analysis’. Although this may be due to incorrect handling, a proportion are attributable to underlying pathology affecting serum, contamination or artefact. In this Lesson of the month we present two case reports. ⋯ In both cases, the laboratory comments had important diagnostic implications. Early identification of lipaemic serum from hypertriglyceridaemic pancreatitis in the first case allowed directed therapy with insulin, and hyperviscous serum from lymphoma in the second allowed directed therapy with plasma exchange and chemotherapy. Other causes of analyser artefact are tabulated to serve as a useful template for hospital doctors in considering underlying causes and practical solutions.
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Takotsubu cardiomyopathy (TC) describes transient left ventricular apical ballooning due to akinetic myocardium. It mimics acute coronary syndrome, with similar electrocardiogram changes and raised troponin, but visible coronary artery stenosis is missing. Patients usually recall a preceding stressful event and post-menopausal women are at greatest risk. ⋯ Treatment is supportive and complications include arrhythmias, cardiac rupture, thrombus formation and congestive cardiac failure. The prognosis is favourable and by definition cardiac function returns to pre-morbid levels. Mortality is rare (1–2%).
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Case Reports
Overfeeding and overhydration in elderly medical patients: lessons from the Liverpool Care Pathway.
This paper describes three elderly patients who were admitted to hospital with aspiration pneumonia. They were kept nil by mouth (NBM) for a number of days, while being given intravenous hydration initially and enteral feeding subsequently. During that time they deteriorated and appeared to be dying, so the Liverpool Care Pathway (LCP) for the dying was used to support their care. ⋯ Vulnerable elderly patients should not be made NBM except as a last resort. Clinicians should be alert to the possibility of refeeding syndrome and overhydration as reversible causes of clinical deterioration, particularly in frail elderly patients. Use of the LCP in these patients provided a unique opportunity to witness the positive effects of withdrawal of excessive artificial nutrition and hydration.
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Gastrointestinal (GI) conditions are common in women of childbearing age. They often present before pregnancy but can arise de novo during pregnancy. ⋯ In this article, we summarise the clinical features, investigation and management of common GI and liver conditions that are incidental to pregnancy, and describe the specific features of pregnancy-related disorders that are less frequently encountered by general physicians. Newer developments in areas that are increasingly encountered in obstetric medical practice, including pregnancy after bariatric procedures, are also described.