Clin Med
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Biography Historical Article
King George III, bipolar disorder, porphyria and lessons for historians.
In the 1960s, Ida Macalpine and Richard Hunter, mother and son psychiatrists, stated that George III's medical records showed that he suffered from acute porphyria. In spite of well-argued criticisms by Geoffrey Dean and Charles Dent based on their extensive clinical experience of the acute porphyrias, Macalpine and Hunter were able to garnish extensive support for their claims from historians, psychiatrists, physicians and the media circus and their view is now surprisingly widely accepted. Recent research of George III's extensive medical records has shown that Macalpine and Hunter were highly selective in their reporting and interpretation of his signs and symptoms and that the diagnosis of the acute porphyria cannot be sustained. The basis for the false claims and the consequences for historians are considered and indicate that there is now an opportunity to reassess George III's contributions to events in his reign.
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Management of SAS and cardiovascular disease risk should be closely linked. It is important to screen for cardiovascular disease risk in patients with SAS and vice versa. ⋯ In the longer-term, CPAP should be used alongside standard cardiovascular risk reduction strategies including robust weight management programmes, with referral for bariatric surgery in appropriate cases. CPAP and NIV should be considered for acute admissions with decompensated cardiac failure.
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Keeping well during Hajj is a challenge for people with diabetes. However, with proactive planning and education, it may prove to be an excellent opportunity for reviewing management and enhancing diabetes education to reduce diabetes-related short- and long-term problems. People with diabetes should have enough time to consider a management plan. It is important that healthcare professionals are well informed regarding the effects of Hajj on diabetes and are able to offer advice, guidance and change of medications as required during pre-Hajj counselling to enable patients to stay healthy.