Cochrane Db Syst Rev
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Leprosy causes nerve damage which can result in nerve function impairment and disability. Corticosteroids are commonly used for treating nerve damage, although the long-term effect is uncertain. ⋯ Corticosteroids are used for treating acute nerve damage in leprosy, but evidence from randomised controlled trials does not show a significant long-term effect. Randomised controlled trials are needed to establish their effectiveness, the optimal regimens and to examine new therapies.
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Esophageal cancer is the seventh leading cause of cancer death worldwide. Traditional Chinese medicinal herbs are sometimes used as an adjunct to radiotherapy or chemotherapy for this type of cancer. ⋯ The included studies were of low quality. The results suggest Zhenxiang capsules or Huachansu injection may not improve short-term therapy effects or one-year survival rate when used as adjunct treatment to chemo- or radiotherapy in the treatment of esophageal cancer. The quality of life may be improved by Huachansu injection. The results suggest that more high-quality trials on Huachansu injection and other Chinese herbal medicines are needed in the future.
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It has been suggested that a time-lag bias exists whereby research studies with striking results are more likely to be stopped earlier than originally planned, published quicker, or both. If time-lag bias exists, new interventions might be mistakenly assumed to be effective. ⋯ Our review shows that trials with positive results are published sooner than other trials. This has important implications for the timing of the initiation and updating of a review, especially if there is an association between the inclusion of a trial in a review and its publication status. It is of particular concern when one considers reviews containing only a small number of studies.
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Cochrane Db Syst Rev · Apr 2007
ReviewPhysical activity programs for promoting bone mineralization and growth in preterm infants.
Lack of physical stimulation may contribute to metabolic bone disease of preterm infants resulting in poor bone mineralization and growth. Physical activity programs in the presence of adequate nutrition might help to promote bone mineralization and growth. ⋯ There is weak evidence from six small randomized trials of poor methodological and reporting quality that physical activity programs might promote moderate short-term weight gain and bone mineralization in preterm infants. The clinical importance of these findings is questionable given the small effect size and low baseline risk of poor bone mineralization and growth in study participants. Data is inadequate to assess harm or long term effects. Current evidence does not justify the standard use of physical activity programs in preterm infants. Further evaluation of this intervention in well designed trials incorporating extremely low birth weight infants who are at high risk of osteopenia is required. Future trials should report on adverse events and long term outcomes including fractures, growth, bone mineralization, skeletal deformities and neurodevelopmental impairment. These trials should address the possibility that nutritional intake (calories, protein, calcium, phosphorus) might modify the effects of physical activity.
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Cochrane Db Syst Rev · Apr 2007
ReviewEditorial peer review for improving the quality of reports of biomedical studies.
Scientific findings must withstand critical review if they are to be accepted as valid, and editorial peer review (critique, effort to disprove) is an essential element of the scientific process. We review the evidence of the editorial peer-review process of original research studies submitted for paper or electronic publication in biomedical journals. ⋯ At present, little empirical evidence is available to support the use of editorial peer review as a mechanism to ensure quality of biomedical research. However, the methodological problems in studying peer review are many and complex. At present, the absence of evidence on efficacy and effectiveness cannot be interpreted as evidence of their absence. A large, well-funded programme of research on the effects of editorial peer review should be urgently launched.