Cochrane Db Syst Rev
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Diverticulitis is an inflammatory complication to the very common condition diverticulosis. Uncomplicated diverticulitis has traditionally been treated with antibiotics with reference to the microbiology, extrapolation from trials on complicated intra-abdominal infections and clinical experience. ⋯ The newest evidence from one RCT says there is no significant difference between antibiotics versus no antibiotics in the treatment of uncomplicated diverticulitis. Previous RCTs have only suggested a non-inferiority between different antibiotic regimes and treatment lengths. This new evidence needs confirmation from more RCTs before it can be implicated safely in clinical guidelines. Ongoing RCTs will be published in the years to come and more are needed. The role of antibiotics in the treatment of complicated diverticulitis has not been investigated yet.
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Flupenthixol, first made available in the UK in 1965, has been used as a treatment for schizophrenia for decades. ⋯ We were surprised that this well-established drug had so few data from trials investigating its absolute effects. We think this is unlikely to be rectified some 50 years after its launch and know that this would not happen today. However, even though data are very limited, flupenthixol may well be worthy of careful investigation - partly to ensure that this inexpensive active drug is not forgotten.
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Cochrane Db Syst Rev · Nov 2012
Early lens extraction compared to standard treatment in acute primary angle closure.
This is the protocol for a review and there is no abstract. The objectives are as follows: To compare the efficacy as well as harms of early lens extraction versus standard treatment in patients with acute primary angle closure.
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Cochrane Db Syst Rev · Nov 2012
Review Meta AnalysisPreoperative physical therapy for elective cardiac surgery patients.
After cardiac surgery, physical therapy is a routine procedure delivered with the aim of preventing postoperative pulmonary complications. ⋯ Evidence derived from small trials suggests that preoperative physical therapy reduces postoperative pulmonary complications (atelectasis and pneumonia) and length of hospital stay in patients undergoing elective cardiac surgery. There is a lack of evidence that preoperative physical therapy reduces postoperative pneumothorax, prolonged mechanical ventilation or all-cause deaths.
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Cochrane Db Syst Rev · Nov 2012
Review Meta AnalysisInterventions for increasing fruit and vegetable consumption in children aged 5 years and under.
Insufficient consumption of fruits and vegetables in childhood increases the risk of future chronic diseases including cardiovascular disease. ⋯ Despite the importance of encouraging fruit and vegetable consumption among children aged five years and under, this review identified few randomised controlled trials investigating interventions to achieve this.