Cochrane Db Syst Rev
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A septic abortion refers to any abortion (spontaneous or induced) complicated by upper genital tract infection including endometritis or parametritis. The mainstay of treatment of septic abortion is antibiotic therapy alone or in combination with evacuation of retained products of conception. Regimens including broad-spectrum antibiotics are routinely recommended for treatment. However, there is no consensus on the most effective antibiotics alone or in combination to treat septic abortion. This review aimed to bridge this gap in knowledge to inform policy and practice. ⋯ We found no strong evidence that intravenous clindamycin alone was better than penicillin plus chloramphenicol for treating women with septic abortion. Similarly, available evidence did not suggest that penicillin plus chloramphenicol was better than cephalothin plus kanamycin for the treatment of women with septic abortion. Tetracyline enzyme antibiotic appeared to be more effective than intravenous penicillin G in reducing the time to fever defervescence, but this evidence was provided by only one study at low risk of bias.There is a need for high-quality RCTs providing reliable evidence for treatments of septic abortion with antibiotics that are currently in use. The three included studies were carried out over 30 years ago. There is also a need to include institutions in low-resource settings, such as sub-Saharan Africa, Latin America and the Caribbean, and South Asia, with a high burden of abortion and health systems challenges.
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Cochrane Db Syst Rev · Jul 2016
Review Meta AnalysisWITHDRAWN: Target-controlled infusion versus manually-controlled infusion of propofol for general anaesthesia or sedation in adults.
July 2016 Owing to the age, retraction of studies (Lehmann 2001; Lehmann 2002; Triem 2006), and possible errors in the conversion of dose for the purpose of analysis the decision has been reached to withdraw the review from the CDSR pending update and amendment of the review. The editorial group responsible for this previously published document have withdrawn it from publication.