Cochrane Db Syst Rev
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Cochrane Db Syst Rev · May 2018
ReviewClonazepam add-on therapy for refractory epilepsy in adults and children.
Epilepsy affects about 50 million people worldwide, nearly a quarter of whom have drug-refractory epilepsy. People with drug-refractory epilepsy have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life. ⋯ There is no evidence from double-blind randomised controlled trials for or against the use of clonazepam as an add-on therapy for adults and children with refractory focal or generalised onset epileptic seizures.