Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Oct 2020
ReviewBranched-chain amino acid supplementation for improving growth and development in term and preterm neonates.
Branched-chain amino acids (BCAAs) play a vital role in neonatal nutrition. Optimal BCAA supplementation might improve neonatal nutrient storage, leading to better physical and neurological development and other outcomes. ⋯ We found no trial data to support or refute the idea that BCAA supplementation affects physical and neurological development and other outcomes in term and preterm neonates.
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Cochrane Db Syst Rev · Oct 2020
Review Meta AnalysisCalcium channel blockers for people with chronic kidney disease requiring dialysis.
Calcium channel blockers (CCBs) are used to manage hypertension which is highly prevalent among people with chronic kidney disease (CKD). The treatment for hypertension is particularly challenging in people undergoing dialysis. ⋯ The benefits of CCBs over other antihypertensives on predialysis blood pressure levels and intradialytic hypotension among people with CKD who required haemodialysis were uncertain. Effects of CCBs on other side effects and cardiovascular death also remain uncertain. Dihydropyridine CCBs may decrease predialysis systolic and diastolic blood pressure level compared to placebo or no treatment. No studies were identified in children or peritoneal dialysis. Available studies have not been designed to measure the effects on costs. The shortcomings of the studies were that they recruited very few participants, had few events, had very short follow-up periods, some outcomes were not reported, and the reporting of outcomes such as changes in blood pressure was not done uniformly across studies. Well-designed RCTs, conducted in both adults and children with CKD requiring both haemodialysis and peritoneal dialysis, evaluating both dihydropyridine and non-dihydropyridine CCBs against other antihypertensives are required. Future research should be focused on outcomes relevant to patients (including death and cardiovascular disease), blood pressure changes, risk of side effects and healthcare costs to assist decision-making in clinical practice.
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Cochrane Db Syst Rev · Oct 2020
Review Meta AnalysisAppendectomy versus antibiotic treatment for acute appendicitis.
This Cochrane review has been withdrawn. The Cochrane review is out of date and included a retracted article in the analysis. ⋯ A new update is expected. The editorial group responsible for this previously published document have withdrawn it from publication.