Gac Med Mex
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Multicenter Study
Detección y genotipificación de Pneumocystis jirovecii en muestras de pacientes mexicanos VIH positivos y negativos.
Pneumocystis jirovecii is an atypical fungus particularly detected in HIV-positive or transplant patients. ⋯ The frequency of Pneumocystis jirovecii infection was high in the studied Mexican population. The most common genotype was different from those reported in other countries. It is necessary to address this health problem through early detection of this infection.
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Biography Historical Article
Manuel González Rivera. Promotor de la educación higiénica en México durante la década de 1940.
This article revisits Doctor Manuel González Rivera's work as a promoter of hygiene education in Mexico during the 1940s. From his classroom at the School of Public Health and head of the Hygiene Education Department of the Ministry of Health and Assistance, González Rivera produced an interesting bibliography on the meaning and importance of hygiene education. Based on three of his most important books, Educación Higiénica (Hygiene Education) (1943), Doña Eugenesia y otros personajes. ⋯ Popular hygiene education materials) (1943) and Enfermedades transmisibles. Cartilla para maestros rurales (Communicable diseases. A booklet for rural teachers) (1944), this article highlights his pedagogical and social work in the design of strategies and tools for health personnel and rural teachers to educate the population in matters of prevention and hygiene habits promotion.
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Multicenter Study
Actitudes de los médicos familiares mexicanos sobre el uso de placebos en la práctica clínica.
The use of placebo has spread in clinical practice despite being controversial. In Mexico, the practice of family medicine is predominantly institutional and works with an essential medications list. ⋯ More impure placebos were used, mainly in healthy worried patients and in those with chronic conditions.
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Cancer is a multifactorial disease that constitutes a serious public health problem worldwide. Prostate cancer advanced stages are associated with the development of androgen-independent tumors and an apoptosis-resistant phenotype that progresses to metastasis. By studying androgen-independent lymphoid nodule carcinoma of the prostate (LNCaP) cells induced to apoptosis by serum elimination, we identified the activation of a non-selective cationic channel of 23pS conductance that promotes incoming Ca2+ currents, as well as apoptosis final stages. arp2cDNA was isolated and identified to be of the same cell type, and mRNA was expressed in Xenopus laevis oocytes, which was found to be associated with the activation of incoming Ca2+ currents and induction to apoptosis. cDNA, which encodes the ARP2 protein, was overexpressed in LNCaP cells and Chinese hamster ovary cells, which induced apoptosis. Our evidence suggests that protein ARP2 overexpression and transit to the cell membrane allows an increased Ca2+ incoming current that initiates the apoptosis process in epithelial-type cells whose phenotype shows resistance to programmed cell death.
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Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects. ⋯ Marijuana must be processed in a laboratory to extract tetrahydrocannabinol and leave cannabidiol, which is the product that can be marketed. Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.