Hippokratia
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L-asparaginase is valuable in treating pediatric acute lymphoblastic leukemia (ALL), yet its use has been associated with lipid profile disturbances. ⋯ To confirm our preliminary results, the role of the administration of L-asparaginase and other medications in the variations in the lipid profile at diagnosis of children with ALL needs to be further elucidated with larger multicentre studies, including more patients from diverse ethnic backgrounds. HIPPOKRATIA 2023, 27 (2):41-47.
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We aimed to evaluate in this study the diagnostic value of the plasmin-α2-plasmin inhibitor complex in patients with malignant tumors and venous thromboembolism (VTE). ⋯ PIC has a sufficient value for the early diagnosis of VTE in patients with malignant tumors. HIPPOKRATIA 2023, 27 (2):37-40.
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Problematic internet use among university students is a rising phenomenon with repercussions worldwide. We aimed to determine the association between time spent online, loneliness, and mental health. ⋯ In our student sample, mental health problems were present in approximately 40 % of participants. They were significantly correlated with problematic internet use, thus complicating the development of essential communication skills in young adults. The higher the internet use, the greater the loneliness felt. Future studies should be more extensive, focusing on the relation of internet use with the type of use, family history of psychopathology, use of substances, and impulsivity. HIPPOKRATIA 2023, 27 (2):31-36.
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In oral and maxillofacial surgery, hard tissue augmentation is provided by materials that accelerate the healing, act as a template for reconstructing bony defects, and stimulate bone production and growth. This study investigated the effects of biocompatible carriers containing active vitamin D and platelet-rich plasma (PRP) on bone defects created in rat calvaria. ⋯ Active vitamin D, PRP, and chitosan formulation positively contributed to the repair of bone defects and induced remarkable clinical improvement. This new delivery approach could be promising for healing bone defects following surgical operations in hard bony tissues. HIPPOKRATIA 2023, 27 (2):48-56.