J Postgrad Med
-
A large number of statistical tools are now used for medical decision in the core activities of diagnosis, treatment and prognosis. These tools provide undeniable help in improving medical outcomes. ⋯ These tools have so completely integrated into medical practice that statistical medicine by itself can stand alone as a medical specialty. Time has arrived to recognize statistical medicine as a medical specialty.
-
Observational Study
Does prehospital time affect survival of major trauma patients where there is no prehospital care?
Survival after major trauma is considered to be time dependent. Efficient prehospital care with rapid transport is the norm in developed countries, which is not available in many lower middle and low-income countries. The aim of this study was to assess the effect of prehospital time and primary treatment given on survival of major trauma patients in a setting without prehospital care. ⋯ Mortality is not associated with prehospital time but with transfers from primary care; probably due to deficient care. To improve survival after major trauma, enhancement of resources for resuscitation and capacity building of on-duty doctors in primary centers should be a priority in countries with limited resources.
-
Osteoarthritis (OA) is a chronic degenerative disorder probably affected by both genetic and environmental causes. Bone morphogenetic proteins (BMPs) are bone-derived factors that can induce new bone formation. Single-nucleotide polymorphisms (SNPs) of BMP5 gene alters the transcriptional activity of the BMP5 promoter that has been involved in OA susceptibility. This case-control study investigated the association of rs1470527 and rs9382564 SNP of BMP5 gene with susceptibility to knee OA (KOA). ⋯ Our results indicate significant association of rs1470527 and rs9382564 polymorphism of BMP5 gene with KOA.