J Res Med Sci
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Considering the increasing incidence rate of ovarian cancer in worldwide and the utility of Gynecologic Imaging Reporting and Data System (GI-RADS) in diagnosing malignant adnexal lesions such as ovarian cancer, we aimed to evaluate the diagnostic performance of this reporting system in differentiating between malignant and benign adnexal lesions. ⋯ Our findings indicated that using GI-RADS, we could quantify the risk of malignancy by such a structured as well as simple reporting system so that the system could be useful for clinicians for performing an appropriate clinical management.
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Large amounts of information have called for increased computational complexity. Data dimension reduction is therefore critical to preliminary analysis. In this research, four variable selection (VS) methods are compared to obtain the important variables in predicting the prognosis of traumatic brain injury (TBI) patients. ⋯ The use of an SVM classifier on optimal subsets given by GA and SFS reveals that wrapper-based methods perform better than filter-based methods in our data set, although all selected subsets, except for the MRMR, were clinically accepted. In addition, for prognosis prediction of TBI patients, a small subset of clinical records during ICU admission is enough to achieve an accepted accuracy.
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Diabetes is one of the most common causes of peripheral neuropathy. There are no known cures for diabetic neuropathy. Pentoxifylline could theoretically be a beneficial treatment for diabetic sensory neuropathy, but there is not enough evidence to prove its effect. The aim of this study was to investigate the effect of pentoxifylline on distal diabetic neuropathy. ⋯ This study showed pentoxifylline could be effective in reducing the symptoms of distal diabetic neuropathy.
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This study aimed to determine the prevalence of glucose metabolism disorder and dyslipidemia in 14-18-year-old girls with different phenotype polycystic ovary syndrome (PCOS). ⋯ The risk of metabolic alterations of glucose metabolism disorder and dyslipidemia in PCOS adolescents was more than non-PCOS counterparts.
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The standard treatment for patients with diffuse large B-cell lymphoma (DLBCL) had been rituximab-based immunochemotherapy. However, the biological and clinical heterogeneity within DLBCL seems to affect treatment outcome. Therefore, the evaluation of miRNA levels might be useful in predicting treatment response and relapse risk. miR-146a is a modulator of innate and acquired immunity and may play an important role in predicting treatment response. The aim of the present study was to compare the expression level of miR-146a in plasma-derived exosomes of responsive DLBCL patients (response to R-CHOP (Rituximab, and Cyclophosphamide, Hydroxydaunorubicin, Oncovine and Prednisone)), refractory DLBCL patients (resistant to R-CHOP), patients receiving R-CHOP, and healthy donors. ⋯ Exosomal miR-146a might be useful as a promising "liquid biopsy" biomarker in predicting treatment response and relapse risk; however, we could not find significant differences due to small sample size.