Natl Med J India
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Observational Study
Slow parasite clearance, absent K13-propeller gene polymorphisms and adequate artesunate levels among patients with malaria: A pilot study from southern India.
Artemisinin-based combination therapy (ACT) is widely used in India and many generic preparations are available. Delayed response has been reported, suggesting inadequate response to artesunate (AS) or genotypic resistance. We designed a prospective observational study to assess the therapeutic response, elaborate pharmacokinetics of AS and identify Plasmodium falciparum kelch 13 (pfk13) propeller gene polymorphisms among hospitalized Indian patients with severe malaria. ⋯ Slow parasite CL was seen with a high parasite burden without genotypic evidence of AS resistance. There is a need to standardize definitions of therapeutic efficacy of AS in cases of severe malaria.
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Knowledge of cognition and its regulation are important meta-cognitive activities, which are crucial for enhancement of learning. Their explicit teaching is meaningful and necessary yet seldom undertaken systematically in medical education programmes. ⋯ Incorporation of meta-cognitive learning practices in medical education offers a basis for enhancing classroom teaching, thereby making it learner-centric. The study helped students in identifying the way they process information and in identifying their preferred methods of assimilating knowledge. Identification of cognitive diversity is a primary pedagogic act for improving competence in learning. Meta-cognitive skills can be harnessed to bring about consonance of the left, right and middle brain cognitive styles to achieve better learning outcomes.
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Administration of intravenous fluids is the most common therapy given to patients admitted to a hospital. Evidence suggests that the use of normal saline (NS) in large quantities is not without adverse effects. Balanced salt solutions (BSS) contain bicarbonate or one of its precursors that act as a buffer, and the electrolyte composition resembles that of plasma. ⋯ In surgical patients, studies found only transient hyperchloraemia and increase in the base deficit in patients receiving NS. Systematic reviews and meta-analyses did not find any significant differences in adverse outcomes such as the need for renal replacement therapy or mortality with the use of saline; however, blood chloride levels were consistently higher with saline compared to BSS. There is a need for larger trials with better methodology to determine if the physiological benefits of BSS translate into better clinical outcomes.