Pak J Med Sci
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To explore the effects of hybrid blood purification on nutritional status and cardiovascular events in patients with end-stage renal disease (ESRD). ⋯ Hybrid blood purification can improve nutritional status and renal function of patients with ESRD, downregulate the expression of inflammatory factors, reduce the degree of inflammatory response, and reduce the risk of cardiovascular events.
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To determine the prevalence of antimicrobial resistance (AMR) in E. coli isolated from urine cultures of patients with uncomplicated cystitis in Pakistan. Another objective was to analyze and compare the resistance rates of E. coli to specific antibiotics, conducting a year-by-year evaluation of these rates to identify trends and changes over the past seven years. ⋯ The national guidelines offer an empirical treatment regimen for patients with uncomplicated cystitis. However, regional variations in antimicrobial resistance (AMR) complicate adherence to these guidelines. Our study supports the use of fosfomycin and nitrofurantoin in management of uncomplicated cystitis, However, ongoing annual regional surveillance is essential to keep clinicians informed about the latest trends in AMR.
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The objective of the study was to assess whether the measurement of the angle of progression in nulliparous women in labour can predict the mode of delivery. ⋯ The angle of progression is a reliable tool for predicting the mode of delivery. Wider angle is associated with vaginal delivery and a narrower angle is associated with cesarean section.
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To identify the disease-causing variant in a family with tuberous sclerosis complex (TSC). ⋯ This study reported a Han-Chinese TSC patient with a recurrent variant TSC2 c.5126C>T (p.P1709L). These findings broaden the phenotypic spectrum of TSC caused by this variant and may contribute to improving TSC genetic diagnoses as well as understanding of its mechanisms.
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To explore the effect of Centratherum antheminticum seeds powder {Cap CASP 500 mg} capsule in diabetes Type-2 (T2DM) patients in Karachi. ⋯ When given standard care to T2D patients, the CASP intervention demonstrated both anti-diabetic and anti-lipidemic effects.