Pak J Med Sci
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To investigate the anticancer effect of Illicium verum against human breast cancer MCF-7 cell line. ⋯ Illicium verum methanol extract possesses very potent anticancer action against MCF-7 cells through cytotoxicity, reduction, and inhibition of cancer cells and by inducing apoptosis.
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To identify the factors that affect outcome in COVID-19 patients in the Pakistani population. ⋯ Results are compatible with international studies; increasing age, number of comorbid conditions and high inflammatory markers are associated with increased mortality. Our study had an exception that female gender had higher mortality as compared to men.
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To assess the postoperative functional, anatomical outcome and complications of various surgical procedures of vaginoplasty performed for patients with vaginal agenesis at our institution. ⋯ Vaginal agenesis is associated with several sexual disorders and despite the various surgical options available, the best procedure in terms of fewer complications and best surgical outcome is yet to be determined.
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To analyze the impact of previous cesarean section on rates of obstetrical hysterectomy among women with placenta previa. ⋯ Strong association of previous number of cesarean section and obstetrical hysterectomy was found with placenta previa. There should be protocols for early identification and prediction of adverse outcomes among women with placenta previa with past history of cesarean section.
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To evaluate the effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in the treatment of depression after ischemic stroke. ⋯ Paroxetine hydrochloride combined with idebenone in the treatment of depression after ischemic stroke can significantly improve HRSD score, enhance clinical efficacy, reduce the levels of inflammatory factors, and increase the levels of antioxidant factors, without a significant increase in adverse reactions. Therefore, it is a safe and effective treatment method.