Pak J Med Sci
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To determine the prevalence, risk factors for macrosomia and pregnancy outcome in women with gestational diabetes (GDM). ⋯ Fetal macrosomia is a common complication among GDM patients. Maternal obesity and poorly controlled diabetes are the common modifiable maternal factors contributing to macrosomia.
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To determine the frequency of psychological stress and associated demographic factors among women with new onset menstrual disorders amid corona pandemic lockdown. ⋯ Among women presented with new onset menstrual disorders in gynecological outpatient, a considerable number reflected increased level of psychological stress during COVID-19 lock down.
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In Pakistan, there is high incidence of congenital and hereditary anomalies (CA) which are a leading cause of infant mortality and morbidity. In order to elucidate the burden and biodemographic correlates of CA, this study was aimed to report the prevalence-pattern and phenotypic attributes of CA in the Hazara population of Khyber Pakhtunkhwa, Pakistan. ⋯ The trend of CA and high incidence of sporadic cases observed in this cohort indicate that nongenetic factors may play a significant role in their etiology which could be minimized by improving the healthcare system.
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To evaluate the effect of Metformin therapy on patients of breast cancer with complications of Type-2 diabetes. ⋯ Type-2 diabetes remains one of the risk factors affecting breast cancer development, progress and prognosis, which could lower the 5-year overall survival rate among breast cancer patients. This is especially evident among menopaused women. Metformin therapy may improve the prognosis of patients of breast cancer complicated with Type-2 diabetes.
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To evaluate the safety and efficacy of tacrolimus combined with glucocorticoids in the treatment of lupus nephritis. ⋯ Tacrolimus combined with glucocorticoids is a safe and effective treatment regimen for patients with lupus nephritis, boasting a variety of benefits, such as significant efficacy and fewer adverse reactions. With such a regimen, the level of inflammatory factors can be significantly reduced, renal function indicators can be ameliorated, the ESR, complement C3, C4, anti-dsDNA antibody positive rate and SLEDAI score of the patients can be significantly improved.