Presse Med
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THE SITUATION: With around 35.000 new cases per year and a 40% mortality rate, colorectal cancer is a real problem of health care in France. Chemotherapy for metastatic disease has completely changed during the ten last years with the emergence of promising new drugs such as oxaliplatin and irinotecan. Oral 5-FU prodrugs have also shown an interesting efficacy in this setting.
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The Hippocratic Oath is twenty-five centuries old. Probably drawn-up by Hippocrates himself, it intervenes in a particular cultural, political and religious context: that of Greece at the time of Pericles. It guaranteed the Asclepiad doctors of the continuity of their knowledge within their community. ⋯ It still remains one of the symbols of the medical profession. Despite its age, it provides insight into some of the questions of medical ethics even today. Its topicality is, without doubt, due to the transcendent nature of the values it proclaimed.
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Randomized Controlled Trial Clinical Trial
[Results of the ECHODIAH clinical trial on hip arthrosis].
The principal objective of ECHODIAH study conducted in patients with hip osteoarthritis was to evaluate the chondroprotective effect of potential of diacerein compared with placebo. The study was conducted over a 3-year period using progression of joint space narrowing as the assessment criterion. ⋯ For aggravation, expressed as joint space narrowing of at least 0.5 mm, there were significantly fewer patients in the diacerein group than in the placebo group; aggravation came significantly later in the diacerhein group. In the population of patients who completed at least 3 months treatment, the sparing effect on joint space narrowing was 32% in the diacerhein group compared with the placebo group. In addition, the mean progression of joint space narrowing was significantly less in patients treated with diacerein; the mean progression decreased from 0.18 mm/year at the end of the first year to 0.13 mm/year at the end of the third year.
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DRUG CLASSES: Three drug classes can be distinguished. The first includes drugs used for symptomatic care. ⋯ The second class corresponds to antiosteoartritis drugs called chondroprotective drugs or structure modifying. The third class includes drugs used for local care.
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Comparative Study
[Diagnosis of aspergillosis and other invasive filamentous fungal infections in hematology].
Invasive filamentous fungal infections (FFI) are difficult to diagnose in the department of hematology; a variety of arguments are necessary to confirm the fungal origin. Our study evaluated prospectively, in a large population in South Eastern France, the diagnostic techniques used ante and post mortem (mycology, anatomopathology, serology and aspergillosis antigens) to prove an FFI. ⋯ Biological diagnosis of FFI relies on the multiplicity of examinations and renewal of mycological sampling.