Presse Med
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LOCAL CARE: Local antiseptics and antibiotics must be avoided to preserve the local bacterial ecosystem of the wound. If surgical debridement is not possible, hypercolloid, alginate or hydrogel dressings should be applied to achieve natural autolytic cleansing. The budding and epithelization phases are also treated either with oily or humid dressings or more modern hypercellular, hydrocolloid and polyurethane film dressings. Other treatments under evaluation include physical means (negative pressure, electrical stimulation) or use of recombinant growth factors.
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A FREQUENT CONDITION IN GERIATRICS: Myelodysplastic syndromes comprise a group of bone marrow disorders characterized by abnormal hematopoetic stem cell clones. They are generally observed after 60 years of age with a peak frequency in the 70-80 year age group. Prevalence is probably underestimated and diagnosis is commonly made in geriatric wards.
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Review
[Drug use in the elderly. Undesirable drug effects in the elderly: epidemiology and prevention].
A COMMON PROBLEM: Adverse drug effects are common and severe in patients over 70. Most concern widely prescribed drugs or drugs with small safety margins.
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IMPORTANCE OF T-LYMPHOCYTES IN SARCOIDOSIS: Sarcoidosis is thought to result from an uncontrolled granulomatous immune response. T-lymphocytes are an essential component of this immune reaction. The recognition of specific antigens through receptors expressed on the cell membrane activates the T-cells, resulting in the expression of effector functions that ultimately control granuloma formation. ⋯ The identification of the antigen(s) recognized by these cells remains an important goal, and may help identify etiologic agents. CYTOKINE PRODUCTION: Considerable progress has been made in characterizing the cytokines produced by T-lymphocytes and other cells participating in the granulomatous reaction. The modulation of the activity of these mediators represents a promising approach for the development of more specific therapeutic agents.