Presse Med
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The most common indication for selective uterine artery angiography is embolisation of symptomatic uterine fibroids (leiomyomas or leiomyomata). It is a safe and effective treatment with worldwide acceptance and may be considered a first-line therapy for women who are finished with childbearing and interested in a minimally invasive uterine-sparing therapy, with only few relative and absolute contraindications remaining. Women interested in pregnancy may be offered embolisation, but only after careful counselling and consideration of other possibilities and patient's reasonable expectations, needs and preferences.
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PCSK9 protein is a key regulator of LDL receptor activity. Gain-of-function mutations in PCSK9 are one of the genetic causes of familial hypercholesterolemia. ⋯ Two PCSK9 inhibitors, alirocumab and evolocumab, have demonstrated a cardiovascular benefit in addition to statin therapy in patients with established cardiovascular disease. A recent European consensus has defined the candidates for PCSK9 inhibitors, e.g., patients with established cardiovascular disease and patients with familial hypercholesterolemia in primary prevention, with substantially elevated LDL-C levels despite maximally tolerated statin with or without ezetimibe therapy.
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Suicide is one of the most important causes of death in prison around the world. In France, suicide rate for prisoners is 18.5 suicides per 10,000 inmates: seven times more common than in the general population. ⋯ No program for prevention of suicidal recurrence has ever been implemented. We propose to adapt « VigilanS », a program already applied in the general population, to the prison population.
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Review Historical Article
[Alpha chain disease: From bedside to bench and back again, an exemplary translation].