Rev Invest Clin
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Randomized Controlled Trial Multicenter Study
METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2.
There is no pharmacological intervention on the treatment of hypoxemia and respiratory distress in COVID-19 patients. ⋯ The addition of MB to the treatment protocols significantly improved SpO2 and respiratory distress in COVID-19 patients, which resulted in decreased hospital stay and mortality. ClinicalTrials.gov: NCT04370288.
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Review Historical Article
THE EVOLVING HISTORY OF THE REVISTA DE INVESTIGACIóN CLíNICA.
The Revista de Investigación Clínica (RIC) was established in 1948. It has been published continuously for 73 years. ⋯ The RIC, since 2015 known as RIC -Clinical and Translational Investigation-, is currently a nationally and internationally recognized scientific journal. This article briefly reviews the most outstanding historical features of the RIC since its foundation.
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I was the Editor-in-Chief of the Revista de Investigación Clínica (RIC) from December 1999-May 2014. In this article, I present a review about how I initiated my experience in the RIC as an author, how I became the Editor-in-Chief, the philosophy of the RIC during my time, the type of publications we had and the citations these papers have received today, the special issues and consensus we published and how the RIC became the official publication of the Mexican Institutes of Health.
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Young women with cancer comprise a special population of patients who experience cancer and oncologic care in a unique way. Recent progress in diagnostic and therapeutic approaches has transformed the landscape of clinical oncology practice. This perspective addresses novel therapies, and some of the main challenges that oncologists face when providing care for young patients in the era of next-generation sequencing and tissue-agnostic approaches through the use of targeted therapies for diverse malignancies.
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Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current understanding of the pathogenesis of autoimmunity and indicate four research avenues whose exploration will bring us closer to resolving fundamental questions that remain unanswered in this enigmatic field.