Rev Invest Clin
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In the past three decades, several technologies designed for other purposes, have been applied in surgery to provide more precision to the surgical procedures and better outcomes. In surgery, innovation requires evidence before widespread implementation of novelties and a continuous quality improvement process to assess benefits and risks. ⋯ Innovation and technology should help to accomplish these conditions, but it must not be the center of surgical practice. We present here our perspective on the main issues related to technology and robotics focusing on evidence-based surgery.
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Transthyretin (TTR) amyloidosis (ATTR) is a progressive condition characterized by multiorgan accumulation of amyloid deposits composed of transthyretin (TTR) fibrils. Over the past decades, despite being a rare disease, ATTR amyloidosis has enabled top-tier therapeutics. In the 90s, organ transplantation was the mainstream therapeutic option and fostered distinct approaches, such as combined liver-heart transplant and domino (sequential) liver transplantation. ⋯ Over the past decade, oriented genetic therapies emerged to prevent, control, and, surprisingly, reverse amyloid deposition. Silencing the TTR gene using different strategies is flourishing, and ongoing trials continue to evaluate diverse approaches to optimize their application. The following perspective describes the currently available treatments for ATTR amyloidosis and the prospects on the potential application of these strategies in other medical fields.
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In this article, a series of original manuscripts and reviews published between 2015 and 2021 in the Revista de Investigación Clínica -Clinical and Translational Investigation- chosen by the Editors are presented. The articles were selected according to what the editors considered are the most outstanding contributions based on originality, and the potential impact of the information provided on translational medicine, rather than on the number of readings and citations.
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Historical Article
MY YEARS AS COEDITOR OF THE REVISTA DE INVESTIGACIóN CLíNICA AND THE 1993-1998 READERS OF OUR JOURNAL.
Some information on our readers during my years as coeditor of the Revista de Investigación Clínica are presented on the basis that readers, unlike editors, have no conflict of interest in evaluating scientific publications. The information provided is restricted to the past 6 years (1993-1998) of my 11 years as coeditor since the number of reader visits to our on-line articles began in 1993. ⋯ These figures suggest that our journal became at the end of the 20th Century a valuable information source for physicians in Mexico. It was the original idea that led Salvador Zubirán to launch this journal in 1948.