Terapevt Arkh
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Comparative Study
[Comparative study of various rapid methods of determining fibrinogen transformation products in the diagnosis of intravascular coagulation and fibrinolysis].
Rapid methods for determination of fibrin-monomer complexes and fibrinogen/fibrin degradation products were studied and compared in 76 patients with different abnormalities in the hemostatic system (acute thromboses, thromboembolism of the pulmonary artery, disseminated intravascular coagulation, immune thrombovasculitis, etc). The control group consisted of 36 healthy donors. ⋯ It is inferred that the ET, PST and SAT are the most suitable for use in clinical medicine, since they are accessible, simple and quick in performance. However, these tests cannot be regarded as similar or interchangeable, since they are used for studying different products of the coagulation and fibrinolytic transformation of fibrinogen.
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Echocardiography and immunological tests were applied to follow and examine 100 patients with grave non-coronarogenic myocardial lesions. Of these, 14 patients had hypertrophic cardiomyopathy (CMP) of the obstructive type, 21 hypertrophic non-obstructive CMP (symmetrical, apical, septal), 15 congestive CMP, 34 nonspecific myocarditis, and 16 alcoholic lesion of the heart. ⋯ Alcoholic lesion of the heart can be recognized on case history specification (including the questioning of the subjects having relations with the patient), and identification of other symptoms of alcoholism. The possibility of making differential diagnosis of the diseases under consideration has been demonstrated.
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The authors discuss the results of the use of therapeutic plasmapheresis (290 sessions) in 56 patients with immunity-mediated diseases: hemorrhagic vasculitis, Goodpasture's syndrome, multiple sclerosis, Guillain-Barre's syndrome, rheumatoid arthritis, partial red cell aplasia, etc. Demonstrate the possibilities of the attainment of positive results provided plasmapheresis is included into the complex of therapeutic measures. ⋯ Infer that the clinical data play the decisive role in the appraisal of the plasmapheresis efficacy. Recommend that intermittent plasmapheresis be widely used for the treatment of internal diseases.