Terapevt Arkh
-
Eighty-six patients with different versions of systemic vasculitis were examined for rheological blood properties and some immunologic characteristics. The relationship between the formation of immune complexes and disorders of rheological characteristics and cell aggregation was established with emphasis on the necessity of correcting these disorders by anticoagulants and deaggregating agents for the treatment of patients with systemic vasculitis to be successful.
-
Experimental Rauscher's virus erythroleukemia (RVE) was employed to study the immunologic mechanisms by which leukemia develops. Experiments were performed on inbred mice, genetically opposite to the disease induction, namely on highly sensitive BALB/c, resistant C57BL/6 and moderately sensitive BDFI animals. ⋯ The recovery of the ALID with OSCAR suppression and RVE regression is a consequence of the development of strictly specific antiidiotypic immune responses (antibodies AIT-anti-OSCAR). It is demonstrated that both passive administration of AIT-anti-OSCAR and induction of their active synthesis brings about a remission of RVE.