Terapevt Arkh
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Comparative Study
[Fatty acids of the omega-3 line in the erythrocytes of Chukchi with myocardial hypertrophy].
A study was made of the fatty acid composition of erythrocytes in the Chukchi aged 30 to 59 with myocardial hypertrophy and in controls. In erythrocytes of the Chukchi the percentage of polyunsaturated fatty acids of omega-3 series including eicosapentaenoic acid was increased (C 20:5), and the percentage of linoleic acid and arachidonic acid was decreased (C 18:2 and C 20:4, respectively) as compared to similar indices of erythrocytes in Muscovites. Myocardial hypertrophy was diagnosed in the Chukchi in whom the percentage C 20:5 in erythrocytes was higher and exceeded that in PL. It was assumed that changes in the fatty acid composition of cell membranes played certain part in disorder of their function and the development of myocardial hypertrophy in the Chukchi.
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An epidemiological survey was conducted among men aged 40 to 59 to study interrelationships of the nutritional patterns in 2 ethnic groups of population and the prevalence of CHD and risk factors of its development. The nutritional habits of the indigenous Kirghiz population in the city of Frunze differed significantly from those of the alien population (Russians, Ukrainians, etc.) and were characterized by a higher consumption of proteins and complex carbohydrates. ⋯ Coronary heart disease, arterial hypertension, smoking, excess body mass, low physical activity were equally common among the Kirghiz and Europeans. Hypercholesterinemia was noted more frequently in Europeans whereas hypertriglyceridemia was more common among the Kirghiz.
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The main parameters of humoral and cellular immunity as well as indices of nonspecific body resistance were studied in 70 patients with iron deficiency anemia. A decrease in the content of the main classes of immunoglobulins and an increase in the CIC level were noted. ⋯ A relative and absolute decrease in the level of T-helpers was revealed. Certain correlation between some clinical and immunological indices was observed.
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Clinico-genetic analysis was performed in 530 patients with chronic bronchitis (CB) and in 760 healthy persons. The frequency of aggravated heredity in the patients' parents was significantly higher than that in the healthy persons' parents (21.3 +/- 1.8 and 12.1 +/- 1.2%, respectively, P less than 0.05), this predominance being associated with such diseases as chronic bronchitis and bronchial asthma. A study of a type of familial aggravation has shown that the probability of CB development in descendants increases substantially if mother suffers from CB, CB morbidity among girls being significantly higher than that among boys. ⋯ A study of the blood antigens ABO, Rh, MN, P, Hp has revealed different sensitivity of persons with different genetic blood markers to CB. Differences in the frequency of antigen combinations were also revealed in the patients and in the healthy persons. The results obtained indicate the appropriateness of further development of genetic investigations in pulmonology.