Terapevt Arkh
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Comparative Study
[The lipid metabolic characteristics of patients with thyroid pathology living in the European north of the USSR].
The blood content of total lipids, triglycerides, total cholesterol, alpha- and beta-lipoprotein cholesterol was measured in 79 patients with diffuse toxic goiter during treatment, in 25 patients with hypothyroidism, in 33 with thyroid hyperplasia, and in 54 healthy women aged 35-60 years from the group of native population of the European North. In all the forms of thyroid dysfunction, the patients manifested dyslipoproteinemia in the form of hypercholesterolemia with an increase of the concentration of beta-cholesterol, hypertriglyceridemia, and with a rise of the cholesterol atherogenic index to 4.0 and over. The signs of dyslipoproteinemia were marked to the greatest degree in thyrotoxicosis, at the stages of euthyroidism attainment or disease remissions.
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Efferent therapy (hemosplenosorption, plasmapheresis, autologous blood radiation) was used in multimodality treatment of 45 patients with sepsis. The therapy exerted a beneficial effect on the disease, favoured the elimination of or minimized intoxication, normalized hemostasis and immunity. Indications for use of hemosplenosorption, plasmapheresis and autologous blood radiation are provided.
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The authors provide disease histories of 4 patients afflicted with genuine systemic lupus erythematosus (SLE). There were 2 men and 2 women who developed acute transverse myelitis (ATM) at an age of 24 to 31 years. Before ATM developed, SLE standing was from 3 to 10 years. ⋯ As for the mechanisms of ATM development, the role of antiphospholipid antibodies is reviewed. The data on familial aggravation of the patients are presented in terms of the development of the antiphospholipid syndrome in their relatives. Emphasis is laid on the necessity of early intensive care with glucocorticoid hormones and cyclophosphamide of patients with associated SLE and ATM in order to improve their prognosis.
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Altogether 52 children suffering from reactive arthritis were placed under observation. In 45 patients arthritis developed after nasopharyngeal infection and was marked by a favourable course with a rapid positive dynamics. 7 children with a history of intestinal infection manifested Reiter's syndrome; in these children arthritis was characterized by a grave and prolonged course and by a high laboratory activity. HLA A10 (RR = 2.7), B27 (RR = 2.5) and DR2 (RR = 2.19) antigen were detected significantly more frequently in ReA patients who suffered nasopharyngeal infection. In children with Reiter's syndrome, the genetic markers of predisposition to the disease were HLA A10 (RR = 5.93) and B27 (RR = 149.1) antigens.