Terapevt Arkh
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Comparative Study
[Erythremia: the activity of erythrocyte antioxidant enzymes and the association with iron deficiency].
Concentration of malonic dialdehyde (MDA) and activity of antioxidant enzymes G-6-PD, glutation peroxidase (GP), glutation reductase, catalase, superoxide dismutase were measured in red cells of patients with polycythemia vera. Plasmic ions Fe3+ were estimated by means of electron-paramagnetic resonance. MDA concentration and antioxidant enzymes (except GP) in polycythemia red cells were found increased, while the activity of selenium-dependent GP was reduced, the inhibition being greatest in severe iron deficiency. It is suggested that GP activity in red cells depends on both selenium levels in the body and concentrations of non-hematic iron.
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For determination of sacroiliitis frequency among natives of Chukotka peninsula a cross-over epidemiological study was conducted. A total of 975 subjects aged 6 years and older were examined. 324 of them (33.2%) had low back pain. X-ray of the pelvis was made in 239 of 324 patients. ⋯ There were marked differences in sex distribution: in males 17.1%, in females 5.7%, RR = 3.9. Out of Chukotka natives with low back pain 2.5% had ankylosing spondylitis, of patients with sacroiliitis 30%. A prospective study of patients with sacroiliitis recorded development of ankylosing spondylitis in 17% of the cases 4 years after the disease onset.
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Intermittent hemofiltration (IH) was used in the treatment of acute renal failure (ARF) in 11 glomerulonephritis patients with nephrotic syndrome. IH was found effective in the above patients as it provides fast relief of interstitial edema of the essential for life organs (the kidneys, liver, lungs, etc.), control of plasma urea and potassium. In nephritis patients with ARF IH is superior to isolated ultrafiltration in providing 10 times higher urea clearance.
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Biliary tracts were investigated in 3420 migrants and 1445 aborigines (Evens, Evenkis) living in Evenkia and Yakutia. Acalculous chronic cholecystitis and cholelithiasis were found in 8.5 and 8.8% of the migrants, respectively. ⋯ The risk to develop biliary disease for migrants grows after 4-5 years of stay in the Far North. It is concluded that biliary pathology in the Far North population was related to ethnic and geographical factors.