Terapevt Arkh
-
Pregnancy in paroxysmal nocturnal hemoglobinuria (PNH) patients has historically been a high-risk situation. The combination of chronic complement-mediated hemolysis caused by the disease and physiological activation of the complement system during pregnancy, significantly worsened the prognosis for the life. For a long time, there were no effective methods for the PNH treatment, and pregnancy in patients seemed to be extremely risky, as it significantly increased the risk of life-threatening complications. The advent of targeted therapy with eculizumab turned the prognosis of this disease upside down: patients began not only to survive, but also to live comparable to healthy people. A comparative analysis of the course and outcomes of pregnancy in patients with PNH treated with eculizumab and in patients without targeted therapy was carried out. ⋯ Thus, eculizumab allows not only to increase the survival rate of patients with PNH, but also to comprehensively improve their quality of life, including the possibility of safe childbirth.
-
Stress is considered as one of the factors associated with the development of many diseases, including the cardiovascular system. The history of studying stress as a risk factor for hypertension began in the first half of the 20th century and continued after the introduction of 24-hour blood pressure monitoring (ABPM) into clinical practice. Then it turned out that there is normotension, stable hypertension and latent hypertension: masked (when clinical BP is within the normal range, and arterial hypertension is recorded according to ABPM and/or self-monitoring of BP) and white coat hypertension (increased BP during a visit to the doctor when normal values of blood pressure according to ABPM or self-monitoring of BP). ⋯ Several models have been proposed for the study of stress, but two of them are more common in clinical studies: the Karasek model (based on an imbalance between job demands and job decision latitude) and the Siegrist model (based on an imbalance of effort and reward). There are only few studies in where attempts have been made to link the increase in BP with the parameters of stress response (for example, with hormonal levels) or genetic predisposition. The review discusses the most significant studies of stress-induced arterial hypertension published to date.
-
Randomized Controlled Trial Multicenter Study
[New opportunities for neuroprotective therapy of patients in the acute and early recovery period of ischemic stroke].
To evaluate the efficacy and safety of Brainmax in comparison with ethylmethylhydroxypyridine succinate and trimethylhydrazinium propionate in patients with ischemic stroke in the acute and early recovery period. ⋯ The present study confirms the superiority of combination therapy with Brainmax over monotherapy with each of the components.
-
Historical Article
[On the history of specialization in the clinic of internal diseases: the role of S.S. Zimnitsky (Kazan) in the formation of nephrology in the USSR].
Russian nephrology, like most clinical disciplines, has passed through two stages in its historical development: at the first stage, it became isolated as an important area of scientific research within the framework of the Soviet clinic of internal diseases, at the second stage it became an independent scientific and educational clinical discipline and medical specialty. The article shows the role of Kazan internist S. S. Zimnitsky as one of the founders of nephrology in the USSR at the first stage of its formation and as one of the leaders of the functional direction in Soviet clinical medicine.
-
Observational Study
[Impact of kidney biopsy on the management of patients in the rheumatology department: retrospective study].
Kidney involvement is a common manifestation of the systemic autoimmune rheumatic diseases. Kidney biopsy is the gold standard for the diagnosis of kidney diseases, however this method has not yet become the standard-of-care in rheumatology practice. ⋯ Our study demonstrates significant value and safety of kidney biopsy in the patients with autoimmune rheumatic conditions. We suggest that kidney biopsy should be implemented in the management of this category of patients.