Terapevt Arkh
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Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease; it is characterized by left ventricular (LV) hypertrophy that cannot be explained by hemodynamic causes. It is believed that sarcomere dysfunction underlies the pathogenesis of this disease, however, only half of patients with the HCM phenotype have mutations in sarcomere-encoding genes. HCM is distinguished by both high genetic and clinical heterogeneity and therefore more studies are seeking to investigate a regulation of gene expression in HCM and how the abnormalities in this process can affect disease phenotype. One of the levels of regulation of gene expression - a post-transcriptional level - is mediated by short non-coding microRNAs that inhibit protein synthesis. ⋯ Levels of certain circulating microRNAs correlate with echocardiographic parameters in HCM patients.
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In April 2023, a well-known therapist and cardiologist, a leading specialist in the study of pathogenetic mechanisms, diagnosis and treatment of arterial hypertension, Vice-President of the Russian Medical Society for Arterial Hypertension, Professor Valery Ivanovich Podzolkov celebrated his anniversary.