Terapevt Arkh
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The recent proceedings of congresses and forums on sepsis were used to write this review. The available definitions of sepsis and ideas on its etiology and pathogenesis are critically analyzed. There is information on new concepts of sepsis and data on a search for new targets, diagnostic and therapeutic approaches, and biomarkers. It is hypothesized that there is a mechanism of action of bacteria on mitochondrial dysfunction and human hormonal regulation with low-molecular weight exometabolites, namely aromatic microbial metabolites.
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The paper deals with the etiology, diagnosis, and treatment of acute respiratory viral infections (ARVI). It considers the currently available methods of etiotropic treatment and the tactics of antiviral therapy. Taking into consideration the fact that ARVI treatment is so far a considerable challenge associated with both the unreasonably widespread use of antibiotics and the giant market saturation with pharmaceuticals for the symptomatic therapy for ARVI, the author gives a critical analysis of medications used for the pharmacotherapy of respiratory viral infections.
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Rheumatoid arthritis (RA) is an inflammatory rheumatic disease of unknown etiology, which is characterized by symmetric, chronic, and erosive arthritis (synovitis) of the peripheral joints and systemic inflammatory involvement of the viscera. Lung pathology, including interstitial lung disease (ILD), is one of the common extra-articular manifestations in RA. ILD is considered to be present in almost 25% of the RA patients. ⋯ The pattern of ILD may be determined by high-resolution computed tomography and may be a major prognostic marker; the development of UIP is worst. The material is dedicated to the successes recently achieved in the diagnosis and therapy of RA-associated ILD. The state-of-the-art of investigations in this area is discussed.
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To study the etiology, clinical manifestations, risk factors, and results of treatment for candidemia (CE) in patients with blood system tumors. ⋯ Candida non-albicans constitute a high proportion among the pathogens of CE. A number of risk factors influencing survival rates in CE have been identified. It is crucial to use echinocandin as a first-line agent as soon as possible after isolation of Candida spp. from blood cultures.
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Comparative Study
[The prevalence and clinical aspects of Barrett's esophagus in the population of Eastern Siberia].
To study the prevalence and clinical aspects of Barrett's esophagus (BE) in natives and newcomers in East Siberia. ⋯ There were ethnic differences in the prevalence of BE, which were prevalent in East Siberia in the Mongoloids as compared to the Caucasoids.