Terapevt Arkh
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Historical Article
[From classification medicine to clinical medicine (the end of the XVIII century--1870s) communication 5. Reforms in therapy in 1840s-1860s].
Reforms of therapy in 1840-1860s are considered: development of the methods of objective assessment of efficacy of some methods of treatment, appearance of experimental pharmacology, introduction of anasthesia.
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To evaluate the efficiency and safety of intravenous infusion of levosimendan in patients with idiopathic pulmonary hypertension (IPH) and its clinical, hemodynamic, and neurohumoral effects. ⋯ 24-hour intravenous levosimendan infusion in patents with FC III-IV IPH and severe RVF causes positive changes in the key hemodynamic parameters and neurohumoral status of the patients and promotes stabilization in those with IPH at 12-week follow-up.
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Comparison of efficacy of 12-month treatment of anemia in patients with chronic kidney disease (CKD) of stage III - IV with a long-acting drug darbepoetin alpha - aranesp and short-acting drug erythropoietin beta - recormon. ⋯ The target level of Hb 110-120 g/l was achieved faster in group 2 than in group 1 (3 and 4 months, respectively). p < 0.05). In the phase of supporting a target Hb level, on the opposite, darbepoetin alpha provided more stable hemopoetin effect than erythropoietin beta, darbepoetin alpha median dose being constant in the course of the study.
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To study the distribution of genotypes in the cytokine genes and their combinations with immunoregulatory activity in patients with type 2 diabetes mellitus (T2DM) and in healthy women. ⋯ The high odds ratio and high specificity of the detected genetic combinations allow one to hope that they will be clinically used as predictors.
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To show distribution of the investigated patients into diagnostic groups, find out the diagnostic value of the levels of hemoglobin and packed cell volume as possible markers of absolute erythrocytosis in the group of patients with polycythaemia. ⋯ Red cell mass and plasma volume measurement is easy and necessary procedure for estimation absolute and "apparent" polycythaemia. Rather common occurrence of different forms of erythrocytosis and in particular "apparent" erythrocytosis must determine certain diagnostic approach according to specific clinical case.