Terapevt Arkh
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Comparative Study
[Efficacy of combined treatment of patients with severe obstructive sleep apnea and arterial hypertension of the second and third degree].
To assess efficacy of two- and three-component antihypertensive treatment (AHT) in patients with severe sleep apnea and arterial hypertension (AH) of the second and third degree in combination with CPAP therapy (continuous positive air pressure) and without it. ⋯ Multicomponent pathophysiologically sound AHT in hypertensive patients with severe obstructive sleep apnea was effective in less than 42% cases. The maximal effect was achieved in combined treatment with CPAP-therapy.
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Comparative Study
[Population association features of interleukine gene polymorphism in khakases with gastroduodenal diseases].
To investigate association of polymorphisms of IL-1 genes and antagonist of IL-2 receptor (IL1Ra). ⋯ It is expedient to define population risk and protective genotypes of development of ulcer associated with Helicobacter pylori in khakases.
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To determine an optimal cyclophosphamide dose in the mobilization scheme providing adequate collection of CD34+ cells in patients with multiple myeloma (MM), to optimize the time of initiation of granulocytic colony-stimulating factor (G-CSF) administration, to study effects of induction therapy schemes on results of mobilization and collection of CD34+ cells. ⋯ Administration of high cyclophosphamide doses in combination with G-CSF is an effective and safe method of BHSC mobilization providing collection of adequate number of CD34+ cells for double autotransplantation in 96.8% patients. Cost effective is the start of G-CSF administration in the fall of leukocytes under 1.0 x 10(9)/l. Cyclophosphamide dose 4 g/m2 provides collection of CD34+ cells number sufficient for two autotransplantations in moderate thrombocytopenia and in less number of substitute transfusions in the absence of serious toxic complications.
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To study epidemiology and risk of chronic obstructive pulmonary disease (COPD) in environmental and climatic conditions of a large industrial center of the Middle Volga Region (the city of Samara). ⋯ Prevalence of COPD in population of Samara is close to that in other large industrial centers of Russia but lower than in larger cities of Europe and in populations of industrial workers. It depends on the age and has special characteristics in males and females.
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Antithymocyte immunoglobulins remain to be one of the most effective immunosuppressants used in transplantology and in the treatment of autoimmune diseases. The unique features of the mechanisms of individual antithymocyte globulin preparations should be borne in mind. Due to its polyclonal nature, thymoglobulin provides a wide spectrum of diverse immunomodulatory effects, which is the basis for its wide use in order to reduce the risk for graft rejection and a graft-versus-host reaction and to treat aplastic anemia.