Terapevt Arkh
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To study the distribution of genotypes in the cytokine genes and their combinations with immunoregulatory activity in patients with type 2 diabetes mellitus (T2DM) and in healthy women. ⋯ The high odds ratio and high specificity of the detected genetic combinations allow one to hope that they will be clinically used as predictors.
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To show distribution of the investigated patients into diagnostic groups, find out the diagnostic value of the levels of hemoglobin and packed cell volume as possible markers of absolute erythrocytosis in the group of patients with polycythaemia. ⋯ Red cell mass and plasma volume measurement is easy and necessary procedure for estimation absolute and "apparent" polycythaemia. Rather common occurrence of different forms of erythrocytosis and in particular "apparent" erythrocytosis must determine certain diagnostic approach according to specific clinical case.
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The paper discusses issues related to the role of basic studies in the development of practical medicine and to the integration of basic science and medical treatment.
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Comparative Study
[Population association features of interleukine gene polymorphism in khakases with gastroduodenal diseases].
To investigate association of polymorphisms of IL-1 genes and antagonist of IL-2 receptor (IL1Ra). ⋯ It is expedient to define population risk and protective genotypes of development of ulcer associated with Helicobacter pylori in khakases.
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Modern diagnosis of rheumatoid arthritis (RA) is based on the ARA criteria with seropositivity detection by the rheumatoid factor (RF). In a clinically evident stage of the disease this factor is highly sensitive and specific (about 90%), but in early RA efficacy of this diagnosis is considerably less. RF-IgM phenotype has limitation: frequent detection of this factor in the absence of RA and unstability of RF-IgM phenotype. ⋯ As specificity of combination of these autoantibodies is almost 100%, their simultaneous determination is indicated in patients with undifferentiated arthritis for specification of the diagnosis. ACCP and antibodies to modified citrullinized vimentin (AMCV) significantly correlate with RA activity, are prognostic factors of rapidly progressive course and can be used for the disease prognosis at its early stage. Present-day data on comparative specificity and sensitivity of ACCP and AMCV are not certain and need further study.