Terapevt Arkh
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To determine surface and intracellular expression of ACE antigen and Bip shaperon on leukemic dendritic cells (LDC); to study expression of ACE genes and Bip, Calnexin, calreticulin shaperons in LDC at diagnosis of acute myeloid leukemia (AML) under standard and stress cultivation. ⋯ LCD and DC of healthy donors are cells which differ by genetic and functional characteristics. Therefore, LDC may response inadequately in development of antitumor immune response. The phenomenon of ACE antigen expression normalization on cell membrane in stress open new opportunities for regulating functional activity of LDC.
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To study nutritional status in chronic obstructive pulmonary disease (COPD) in relation to the serum content of adipose tissue hormones. ⋯ An integrated assessment of the degree of protein-energy malnutrition and measurement of the level of adipose tissue hormones should be made when nutritional status is studied in patients with COPD.
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To determine the role of neurohumoral dysfunction and overweight in a clinical course of arterial hypertension (AH). ⋯ One of the mechanisms forming and sustaining AH in patients with overweight is leptin-dependent sympathetic hyperactivity while serotonin system activation is more important for patients with normal body weight. Hypertensive patients with obesity demonstrate insulin-dependent hyperleptinemia.
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To investigate comorbidity in chronic obstructive pulmonary disease (COPD) and its contribution to lethality of patients with pulmonary disease. ⋯ The CI rose with growing severity of a COPD course (p < 0.01). Follow-up of 77 COPD patients for 3-5 years distinguished a group of patients with unfavorable outcomes. In lethal outcomes CI-3 points occurred significantly more frequently (p < 0.001). A significant correlation exists between CI and time from the moment of CI estimation to the patient's death (r = -0.54; p < 0.05). Thus, CI can be used in clinical practice as a simple method of risk of death for COPD patients. A rise of CI over 3 scores indicates a high risk of a COPD patient's death which should be considered in management of COPD patients.