Terapevt Arkh
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To study the effects of F(ab')2 fragments of the monoclonal antibody (monAB) FRaMon against glycoproteins (GP) IIb-IIIa on platelet aggregating activity in vitro and after injection to healthy volunteers. ⋯ F(ab')2 fragments of monAB FRaMon effectively inhibited aggregating ability both in vitro and after injection to healthy volunteers and could be suggested as a basis for development of a new GP IIb-IIIa antagonist.
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Case Reports Comparative Study
[Neuritic bleeding and undiscovered mechanisms of regulation of the hemostasis system].
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Randomized Controlled Trial Comparative Study Clinical Trial
[Comparative study of spirapril (quadropril) and amlodipine efficacy. Results of randomized trial in patients with mild to moderate arterial hypertension].
To compare in the non-blind randomised parallel study the efficiency of quadropril and amlodipine in the treatment of mild to moderate arterial hypertension. ⋯ Both quadropril and amlodipine demonstrated a comparable antihypertensive effect although in 11 of 40 patients in the amlodipine group a dose increase was necessary and tolerability of quadropril was better.
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Comparative Study Clinical Trial
[Low doses of alpha-interferon preparations in the treatment of patients with chronic myeloleukemia].
To compare the effects of low-dose alpha-interferons with those of cytostatics (hydroxyurea or myelosan) on survival of patients and duration of chronic phase of chronic myeloid leukemia (CML). ⋯ Treatment of CML with low-dose alpha-interferons increases duration of the CML chronic phase and survival of CML patients.