Terapevt Arkh
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To establish the incidence of HLA-B27 among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made of all the natives of the two settlements of eastern Chukot Peninsula (Sireniki and Novo-Chaplino). At the moment of examination altogether 640 natives lived in both settlements. Of these, 464 persons (72.5%) could be examined clinically; HLA typing could be performed in 439 persons (68.6%). ⋯ Half-breeds occupied an intermediate position between the two groups. The frequency of NLA-B27-positive cases was 29.7% among them. 7 patients were diagnosed to have diseases belonging to the group of spondyloarthropathies. 2 persons presented with ankylosing spondyloarthritis, 2 with Reiter's syndrome, 2 with undifferentiated spondyloarthropathies and 1 with juvenile chronic arthritis. All the patients with ankylosing spondyloarthritis and Reiter's syndrome appeared HLA-B27-positive.
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To determine the HLA-B27 gene subtypes associated with joint diseases we examined 55 patients (35 with ankylosing spondylarthritis (AS), 13 with rheumatoid arthritis (RA), 5 with Reiter's syndrome, 2 with psoriatic arthritis). DNA amplification combined with sequence specific oligonucleotide hybridization were used to identify six HLA-B27 gene alleles. In the AS patients group the frequency of HLA-B2705 variant was found to be different significantly from that in healthy West Siberia Caucasians and distribution of HLA-B27 gene allele variants among AS patients in East Russia differed from that in West regions of Russia. DNA typing data can be useful together with other criteria for diagnosis of AS in a early onset.
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Altogether 156 Evenks and 162 Evens were examined in the reindeer regions of Evenkia and the Yakut Republic located in the extreme north of Russia. Seasonal changes in the concentration and ratio of bile lipids were discovered. The conclusion is made that space and time coordinates are of importance for the diagnosis and treatment of biliary tract diseases in northern nations.
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To establish the prevalence of spondyloarthropathies among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made with a direct medical examination of the natives of the two settlements of Eastern Chukot Peninsula: Sireniki and Novo-Chaplino where the main part of Eskimos live. During expedition, 640 natives aged over 6 years lived in both settlements (382 and 258 respectively). 464 persons (72.5%) were examined. ⋯ The incidence of ankylosing spondyloarthritis among Eskimos amounted to 0.9%, Reiter's syndrome to 0.5%, and undifferentiated spondyloarthropathies to 0.5%. Thus the one-stage expedition examination of the indigenous population of Chukotka Peninsula (Eskimos and Chukchi) has shown that diseases belonging to the group of spondyloarthropathies are widely prevalent among Eskimos.