Terapevt Arkh
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Randomized Controlled Trial
[Soy protein as part of a low-protein diet is a new direction in cardio- and nephroprotection in patients with 3B-4 stages of chronic kidney disease: prospective, randomized, controlled clinical study].
It has been established that the use of a low-protein diet (LPD) in combination with ketoanalogues (KA) of essential amino acids can contribute to cardio- and nephroprotection in chronic kidney disease (CKD). Moreover, it has been shown that replacing part of the animal protein with soy protein (SP) in the diet contributed to more pronounced nephro- and cardioprotection in CKD, however, the data, available in the literature, are mainly represented by experimental studies. ⋯ The use of LPD with substitution of animal protein with soy protein + KA provides a more pronounced effect on nephro- and cardioprotection as well as maintenance of nutritional status, than conventional LPD + KA in patients with 3B4 stages of CKD.
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Randomized Controlled Trial Multicenter Study
[New opportunities for neuroprotective therapy of patients in the acute and early recovery period of ischemic stroke].
To evaluate the efficacy and safety of Brainmax in comparison with ethylmethylhydroxypyridine succinate and trimethylhydrazinium propionate in patients with ischemic stroke in the acute and early recovery period. ⋯ The present study confirms the superiority of combination therapy with Brainmax over monotherapy with each of the components.
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Historical Article
[On the history of specialization in the clinic of internal diseases: the role of S.S. Zimnitsky (Kazan) in the formation of nephrology in the USSR].
Russian nephrology, like most clinical disciplines, has passed through two stages in its historical development: at the first stage, it became isolated as an important area of scientific research within the framework of the Soviet clinic of internal diseases, at the second stage it became an independent scientific and educational clinical discipline and medical specialty. The article shows the role of Kazan internist S. S. Zimnitsky as one of the founders of nephrology in the USSR at the first stage of its formation and as one of the leaders of the functional direction in Soviet clinical medicine.
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Observational Study
[Impact of kidney biopsy on the management of patients in the rheumatology department: retrospective study].
Kidney involvement is a common manifestation of the systemic autoimmune rheumatic diseases. Kidney biopsy is the gold standard for the diagnosis of kidney diseases, however this method has not yet become the standard-of-care in rheumatology practice. ⋯ Our study demonstrates significant value and safety of kidney biopsy in the patients with autoimmune rheumatic conditions. We suggest that kidney biopsy should be implemented in the management of this category of patients.
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To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. ⋯ C3-GP is a variant of severe complement-mediated glomerular damage with unfavorable renal prognosis, which requires timely personalized expert-level diagnostics with clarification of etiopathogenesis of the disease followed by therapy aimed at achieving remission to improve outcomes.