Turk J Med Sci
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To evaluate the changes in the number of NADPH diaphorase (NADPH-d) stained neurons in the vagal nuclei in a chronic esophagitis model. ⋯ The increased nitric oxide expressions in the dorsal vagal nucleus and nucleus tractus solitarius are most probably due to adaptive changes to disturbed esophageal motility and mucosal damage.
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Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the Turkish population was investigated. ⋯ Our results show that the TIMP-2 -418 (GC) genotype had a putative protective effect against prostate cancer.
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To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects. ⋯ The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.
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To investigate the value of measuring liver enzymes, red cell distribution width (RDW), and mean platelet volume (MPV) in predicting the development of gestational diabetes mellitus (GDM). ⋯ Our study results suggest that ALT, GGT, PCT, and PDW may be useful as predictors of impending GDM.
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To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. ⋯ High preoperative PSA levels, PSMs, and tumors with high GS at the margins have a poor prognostic impact, and they correlate with a higher rate of BCR. Close follow-up of patients with PSMs with high GS and high levels of preoperative PSA is recommended.